Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection-the good, bad and deadly
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.
Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation. The pathophysiology of hepatic ischemia-reperfusion includes a number of mechanisms that contribute to various degrees in the overall injury. Some of the topics discussed in this review include cellular mechanisms of injury,...
متن کاملRegulatory Mechanisms of Injury and Repair after Hepatic Ischemia/Reperfusion
Hepatic ischemia/reperfusion injury is an important complication of liver surgery and transplantation. The mechanisms of this injury as well as the subsequent reparative and regenerative processes have been the subject of thorough study. In this paper, we discuss the complex and coordinated responses leading to parenchymal damage after liver ischemia/reperfusion as well as the manner in which t...
متن کاملHepatic ischemia-reperfusion injury.
24 Interferon regulatory factor-1 (IRF1) is a nuclear transcription factor that induces inflammatory 25 cytokine mediators and contributes to hepatic ischemia-reperfusion injury (I/R). Currently, no 26 strategies to mitigate IRF1-mediated liver damage exist. Interferon regulatory factor 2 (IRF2) is a 27 structurally similar endogenous protein that competes with IRF1 for DNA binding sites in IRF...
متن کاملRole of mitogen-activated protein kinases in ischemia and reperfusion injury : the good and the bad.
There is growing evidence that multiple mitogen-activated protein (MAP) kinases are activated during ischemia and/or reperfusion and may contribute to the structural and functional changes after myocardial ischemia. A new study by Yue et al1 in this issue of Circulation Research attempts to address the role of MAP kinases in ischemic myocardium and suggests that ERK1/ERK2 is part of a “survival...
متن کاملEffects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model
Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries. We aimed to determine the beneficial effects of silibinin, a potent radical scavenger on liver I/RI.Materials...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2011
ISSN: 0815-9319
DOI: 10.1111/j.1440-1746.2010.06584.x